NeuraMap has an easy to follow wizard that takes you through each step of setting up your map.

To start working with a new map, select File->New and select the map image. This example shows a Petroleum Map. You can also select map types of Geological Cross Section, Seismic Section, or General Plot. Choose NEXT.
Name the Workspace that will hold your work. The workspace will allow you to open and work with several maps at one time. NEXT
Select the Capture types that you will be working with in this map. Additional types can be added later if you do not know. NEXT
Select the map projection. FINISH
Begin calibrating the map. Click on a calibration point. Set units and point value. Repeat with other calibration points.

NOTE: Well locations are commonly used for calibrating maps. It is possible to digitize a map with no projection and no calibration.